HTS produces massive movement of water out of edematous swollen cells and into the blood vessels. This movement of water out of the brain can reduce swelling and improve cerebral blood flow. This specific action of HTS is due to its reflection coefficient of 1. The high numbers of particles in the solution pull water from a low-pressure compartment to a higher-pressure one. Compared with another osmotic diuretic such as mannitol, in which the reflection coefficient is (allowing some leakage outside the blood vessels), HTS will not leak outside the capillaries in the presence of an intact blood-brain barrier.