Life Science > Metabolomics > Learning Center > Metabolic Pathways > ATP Synthase
Dr. Jason Karp is a nationally-recognized running and fitness coach and owner of Run-Fit. As one of America’s foremost running experts and the 2011 IDEA National Personal Trainer of the Year, he has been profiled and interviewed in a number of publications. A rare combination of education and expe rience, he holds three degrees in exercise science, including a . in exercise physiology from Indiana University and a master’s degree from the world-famous Human Performance Laboratory at the University of Calgary. No other running coach or personal trainer has the combination of credentials, education, and experience. A prolific writer who is more widely published than anyone in the fitness or coaching industries, he has more than 200 articles published in numerous international running, coaching, and fitness magazines and scientific journals, is the author of five books, including Running for Women and Running a Marathon For Dummies (of the internationally-known For Dummies brand), and is a frequent speaker at international fitness and coaching conferences. A former high school and college cross country and track coach, Jason is a nationally-certified running coach through USA Track & Field, has taught USA Track & Field’s highest level coaching certification, has led elite coaching camps at the . Olympic Training Center, and is sponsored by PowerBar and Brooks. He has been a runner since sixth grade and was a member of the silver-medal winning . Masters Team at the 2013 World Maccabiah Games in Israel. ... read more.
Hydrolysis of the phosphate groups in ATP is especially exergonic , because the resulting orthophosphate group is greatly stabilized by multiple resonance structures , making the products (ADP and P i ) much lower in energy than the reactant (ATP). The high negative charge density associated with the three adjacent phosphate units of ATP also destabilizes the molecule, making it higher in energy. Hydrolysis relieves some of these electrostatic repulsions, liberating useful energy in the process by causing conformational changes in enzyme structure.