Steroid 11 beta-hydroxylase activity

As a mitochondrial P450 system, P450c11 is dependent on two electron transfer proteins, adrenodoxin reductase and adrenodoxin that transfer 2 electrons from NADPH to the P450 for each monooxygenase reaction catalyzed by the enzyme. In most respects this process of electron transfer appears similar to that of P450scc system that catalyzes cholesterol side chain cleavage. [9] Similar to P450scc the process of electrons transfer is leaky leading to superoxide production. The rate of electron leakage during metabolism depends on the functional groups of the steroid substrate. [10]

steroid ster·oid (stěr'oid', stēr'-)
n.
Any of numerous naturally occurring or synthetic fat-soluble organic compounds having as a basis 17 carbon atoms arranged in four rings and including the sterols and bile acids, adrenocortical and sex hormones, certain natural drugs such as digitalis compounds, and the precursors of certain vitamins. Also called steroid hormone . adj. ste·roid·al (stĭ-roid', stě-)
Relating to or characteristic of steroids or steroid hormones.

Al-Jurayyan (1995) reported that 78 Saudi children with CAH were seen at a hospital in Riyadh over a 10-year period. Of these, 20 (%) patients from 11 families had 11-beta-hydroxylase deficiency. Pseudoprecocious puberty in males and variable degrees of virilization in females led to wrong sex assignment in 7 (%). Neonatal salt-wasting before treatment occurred in 3. Moderate to severe hypertension associated with hypokalemia was present in another 6. In 4 sibs, hypertension persisted despite adequate hydrocortisone therapy. Al-Jurayyan (1995) observed that the disorder appeared to be relatively frequent in the Saudi Arabian population.

Steroid 11 beta-hydroxylase activity

steroid 11 beta-hydroxylase activity

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