7-8 and then extracted with MTBE (70 ml_). The extract was washed with water (35 ml_) and concentrated in vacuo to give an oil. The oil was then dissolved in EOH (50 ml_) and treated with HOAc (10 ml_) and thiourea ( g, mmol). The mixture was heated at reflux overnight and then cooled to ambient temperature. The solids were filtered and washed with EtOH (10 ml_). The filtrate and the wash were combined and concentrated in vacuo, treated with MTBE (140 ml_) and washed successively with 10% aqueous Na 2 C0 3 and water. The mixture was concentrated in vacuo to give an oil. The oil was dissolved in MeCN (72 ml_), heated to -50 °C and then dibenzoyl-L-tartaric acid ( g, mmol) in acetonitrile (22 ml_) was added slowly. Seed crystals were added at -50 °C. The resultant slurry was stirred at 45-50 °C for 5 h, then cooled down to ambient temperature and stirred at ambient temperature overnight. The solids were filtered and washed with MeCN (2x 22 ml_). The wet cake was treated with MeCN (150 ml_) and heated to 50 °C. The slurry was stirred at 50 °C for 5 h, cooled over 1 h to ambient temperature and stirred at ambient temperature overnight. The solids were collected by filtration, washed with MeCN (2 x 20 ml_), dried under vacuum to give the title compound ( g, 34% overall yield, % purity, % ee) as a white solid. 1 H NMR (500 MHz, DMSO-d 6 ) δ ppm (m, 6H), 1 .13 (m, 4H), 1 .51 (m, 2H), 1 .58 (q, J – Hz, 2H), (s, 2H), (s, 3H), (s, 2H), (m, 2H), (m, 1 H), (m, 4H), (m, 2H), (m, 4H). EI-LCMS m/z 284 (M + +1 of free base).
Depending on the individual goals a beginner will find comfortable Turinabol doses in the range of 15 – 30mg per day, although this is considered a low dose range where gains will not be exceptionally dramatic by any means. Such a Turinabol dose would provide noticeable but steady lean gains and almost nothing in the way of unwanted side effects except for those most sensitive. Intermediate users would find greater progress in the way of strength and mass gains upwards of 30 – 50mg per day with still very low incidences or chances of unwanted side effects. Advanced Turinabol doses land in the range of 50 – 80mg per day sometimes higher which would of course provide more dramatic strength and mass gains but at the expense of increased androgenic side effects at such an increased Turinabol dose. In general most users find satisfactory results in the middle of the total previously mentioned doses, which would be around 50mg per day. Doses lower than 40mg per day tend to be utilized merely for the preservation of lean mass during fat loss and cutting phases.