Oral steroids for bell's palsy

As a glucocorticoid , the lipophilic structure of prednisolone allows for easy passage through the cell membrane where it then binds to its respective glucocorticoid receptor (GCR) located in the cytoplasm. Upon binding, formation of the GC/GCR complex causes dissociation of chaperone proteins from the glucocorticoid receptor enabling the GC/GCR complex to translocate inside the nucleus. This process occurs within 20 minutes of binding. Once inside the nucleus, the homodimer GC/GCR complex binds to specific DNA binding-sites known as glucocorticoid response elements (GREs) resulting in gene expression or inhibition. Complex binding to positive GREs leads to synthesis of anti-inflammatory proteins while binding to negative GREs block the transcription of inflammatory genes. [28]

Prednisone is a drug that belongs to the corticosteroid drug class, and is an anti-inflammatory and immune system suppressant. It's used to treat a variety of diseases and conditions, for example: inflammatory bowel disease (Crohn's disease and ulcerative colitis ), lupus , asthma , cancers , and several types of arthritis .

Common side effects are weight gain , headache , fluid retention, and muscle weakness . Other effects and adverse events include glaucoma , cataracts , obesity , facial hair growth, moon face, and growth retardation in children. This medicine also causes psychiatric problems, for example: depression , insomnia , mood swings , personality changes, and psychotic behavior. Serious side effects include reactions to diabetes drugs , infections, and necrosis of the hips and joints.

Corticosteroids like prednisone, have many drug interactions ; examples include: estrogens , phenytoin ( Dilantin ), diuretics, warfarin ( Coumadin , Jantoven ), and diabetes drugs . Prednisone is available as tablets of 1, , 10, 20, and 50 mg; extended release tablets of 1, 2, and 5mg; and oral solution of 5mg/5ml. It's use during the first trimester of pregnancy may cause cleft palate . This medicine is secreted in breast milk and can cause side effects in infants who are nursing . You should not stop taking prednisone abruptly because it can cause withdrawal symptoms and adrenal failure. Talk with your doctor, pharmacist, or other medical professional if you have questions about beta-blockers. Talk with your doctor, pharmacist, or other medical professional if you have questions about prednisone.

If you notice other effects not listed above, contact your doctor or pharmacist. In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Oral corticosteroids have traditionally been prescribed to reduce facial nerve inflammation in patients with Bell's palsy. Prednisone is typically prescribed in a 10-day tapering course starting at 60 mg per day. A 2004 Cochrane review and meta-analysis of three randomized controlled trials comparing corticosteroids with placebo found small and statistically nonsignificant reductions in the percentage of patients with incomplete recovery after six months (relative risk [RR] = ; 95% confidence interval [CI], to ) and the percentage of patients with cosmetic complications (RR = ; 95% CI, to ). 14 However, these trials included only 117 patients; larger prospective trials are needed to establish the benefit of corticosteroids.

There is no single treatment for Bell's palsy. The approach should vary from patient to patient depending on the severity of their condition. For mild cases, a therapy can be helpful and no further medication is needed. However, in more severe cases, medical intervention is needed to prevent further damage to the nerves and for faster recovery of the patient. The common medication or treatment for this disorder is the use of antiviral drugs such as acyclovir which is used to fight viral infections. The treatment is commonly combined with an anti-inflammatory drug such as the steroid prednisone which is used to reduce inflammation and swelling. It is noted that these combination is effective in improving facial function by limiting or reducing damage to the nerve. Analgesics such as aspirin, acetaminophen, or ibuprofen may also be used to relieve pain. A study conducted by University of Alexandria in Egypt validated the efficacy of using steroids in the treatment of patients with Bell's palsy. The rate of satisfactory recovery in all steroid treated patients was higher (79 of 93 patients) which is 85%. There was also evidence that steroid treatment of Bell's palsy is effective more than 24 hours after the onset of facial paralysis. With these development, more doctors are now using steroids to help patient recover from this disorder.

Oral steroids for bell's palsy

oral steroids for bell's palsy

There is no single treatment for Bell's palsy. The approach should vary from patient to patient depending on the severity of their condition. For mild cases, a therapy can be helpful and no further medication is needed. However, in more severe cases, medical intervention is needed to prevent further damage to the nerves and for faster recovery of the patient. The common medication or treatment for this disorder is the use of antiviral drugs such as acyclovir which is used to fight viral infections. The treatment is commonly combined with an anti-inflammatory drug such as the steroid prednisone which is used to reduce inflammation and swelling. It is noted that these combination is effective in improving facial function by limiting or reducing damage to the nerve. Analgesics such as aspirin, acetaminophen, or ibuprofen may also be used to relieve pain. A study conducted by University of Alexandria in Egypt validated the efficacy of using steroids in the treatment of patients with Bell's palsy. The rate of satisfactory recovery in all steroid treated patients was higher (79 of 93 patients) which is 85%. There was also evidence that steroid treatment of Bell's palsy is effective more than 24 hours after the onset of facial paralysis. With these development, more doctors are now using steroids to help patient recover from this disorder.

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