Oral morphine to fentanyl patch

Decreased fetal weights were observed in pregnant rats treated with 20 mg/kg/day morphine sulfate ( times the HDD) from Gestation Day 7 to 9. There was no evidence of malformations despite maternal toxicity (10% mortality). In a second rat study, decreased fetal weight and increased incidences of growth retardation were noted at 35 mg/kg/day ( times the HDD) and there was a reduced number of fetuses at 70 mg/kg/day ( times the HDD) when pregnant rats were treated with 10, 35, or 70 mg/kg/day morphine sulfate via continuous infusion from Gestation Day 5 to 20. There was no evidence of fetal malformations or maternal toxicity.

Oral morphine to fentanyl patch

oral morphine to fentanyl patch

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