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A 2009 review found that the evidence supporting the effectiveness of zinc is mixed with respect to cough, [11] and a 2011 Cochrane review concluded that zinc "administered within 24 hours of onset of symptoms reduces the duration and severity of the common cold in healthy people". [23] A 2003 review concluded: "Clinical trial data support the value of zinc in reducing the duration and severity of symptoms of the common cold when administered within 24 hours of the onset of common cold symptoms." [24] Zinc gel in the nose may lead to long-term or permanent loss of smell. The FDA therefore discourages its use. [25]

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