Bioconversion of steroids

NET displays 8 times higher progestational activity than progesterone [29] . It is also a potent progestogen and binds to the PR with approximately 150% of the affinity of progesterone . [3] In contrast, its parent compounds, testosterone , nandrolone (19-nortestosterone), and ethisterone (17α-ethynyltestosterone), have 2%, 22%, and 44% of the relative binding affinity of progesterone for the PR. [5] Unlike NET, its major active metabolite 5α-dihydro-NET (5α-DHNET), which is formed by 5α-reductase , has been found to possess both progestogenic and marked antiprogestogenic activity, [30] although its affinity for the PR is greatly reduced relative to NET at only 25% of that of progesterone. [3] NET produces similar changes in the endometrium and vagina and is similarly thermogenic in women compared to progesterone, which is in accordance with its progestogenic activity. [31]

Intraocular pressure, glaucoma
Have you heard of DHEA causing high IOP (intraocular pressure) or possibly temporary glaucoma. I have been taking DHEA for about a year. I like the benefits it has provided both physically and mentally. However my last flight physical for the military showed me having high IOP in both eyes. Two days after I stopped taking DHEA my pressures where back to normal.
   I have not heard of this side effect yet, and I have not seen it mentioned in the medical literature, however it is a possibility to consider. There's a lot we don't know about the long term effects of DHEA. If your IOP is increased again after restarting the DHEA and then returns to normal after stopping, then that would make it quite likely that in your case it was involved.

Danish scientist Hans Christian Gram devised a method to differentiate two types of bacteria based on the structural differences in their cell walls. In his test, bacteria that retain the crystal violet dye do so because of a thick layer of peptidoglycan and are called Gram-positive bacteria . In contrast, Gram-negative bacteria do not retain the violet dye and are colored red or pink. Compared with Gram-positive bacteria, Gram-negative bacteria are more resistant against antibodies because of their impenetrable cell wall. These bacteria have a wide variety of applications ranging from medical treatment to industrial use and Swiss cheese production.

For instance the chemical synthesis of cortisone required 37 steps under extreme conditions. One of the steps is introduction of oxygen at position 11 in the steroid nucleus. The microbe Rhizopus arrhizus being capable of hydroxylating progesterone (a steroid) at position 11 is used in the fermentation to produce progesterone an intermediate in the synthesis of cortisone. Thus, this reduced the chemical synthesis steps from 37 to 11 and all under normal conditions, thereby making it economical and easy. Steroids are used as anti-inflammatory agents, contraceptives, treating hormonal insufficiency, allergy, skin diseases etc.

   This section cited in 22 Pa. Code §   (relating to high school education).
SCHEDULING AND LEARNING OPTIONS
§ .  Scheduling.  (a)  Kindergarten programs shall provide each kindergarten student with at least 2 1/2 hours of instruction each day for the full school term unless the school district, including charter schools, obtains prior Department approval for an alternative kindergarten program.  (b)  A school district, including charter schools, shall obtain approval of the Department prior to scheduling 1/2-day sessions other than in kindergarten under subsection (a). A school district is not required to obtain approval of the Department prior to scheduling 1/2 day sessions for prekindergarten under subsection (e).  (c)  A school district shall obtain approval of the Department prior to establishing a new school or changing school organization.  (d)  Planned instruction offered in summer school may be designed as credit or noncredit offerings.  (e)  School districts with prekindergarten programs shall provide prekindergarten students with at least 2 1/2 hours of instruction each day for the full school term unless the school district obtains prior Department approval for an alternative prekindergarten program.
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Bioconversion of steroids

bioconversion of steroids

For instance the chemical synthesis of cortisone required 37 steps under extreme conditions. One of the steps is introduction of oxygen at position 11 in the steroid nucleus. The microbe Rhizopus arrhizus being capable of hydroxylating progesterone (a steroid) at position 11 is used in the fermentation to produce progesterone an intermediate in the synthesis of cortisone. Thus, this reduced the chemical synthesis steps from 37 to 11 and all under normal conditions, thereby making it economical and easy. Steroids are used as anti-inflammatory agents, contraceptives, treating hormonal insufficiency, allergy, skin diseases etc.

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