Aspirin and nonsteroidal anti-inflammatory drugs inhibit amyloid-beta aggregation

Aspirin and many other nonsteroidal anti-inflammatory drugs (NSAIDs), (eg, ibuprofen, naproxen, indomethacin, and ketorolac) are carboxylic acids [ 1 ]. Their pKa values range from (aspirin) to (ibuprofen). As such, they are not ionized at the acidic pH found in the gastric lumen and thus can be absorbed across the gastric mucosa. Once these drugs move from the acidic environment of the gastric lumen into the pH–neutral mucosa, the drugs ionize and are trapped temporarily in epithelial cells where it may damage these cells.

Upala može igrati važnu ulogu u razvoju Alzheimerove bolesti. Također postoje i pojedini dokazi iz ispitivanja populacije u zajednici da ljudi koji primaju protuupalne lijekove za različita medicinska stanja mogu imati manju vjerojatnost razvoja Alzheimerove bolesti. Kod ovog Cochrane sustavnog pregleda, uključeno je četrnaest studija. Aspirin, steroidni i nesteroidni protuupalni lijekovi (tradicionalni i selektivni inhibitori ciklooksigenaze-2 (COX-2)) nisu pokazali značajnu korist u liječenju Alzheimerove bolesti. Stoga se uporaba ovih lijekova ne može preporučiti za liječenje Alzheimerove bolesti.

FDA reviewed a meta-analysis of randomized clinical trials of cardiovascular and upper gastrointestinal events with non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs), conducted by the Coxib and traditional NSAID Trialists’ (CNT) Collaboration of the Clinical Trial Service and Epidemiological Studies Units at Oxford University. 2 We also reviewed observational studies and other scientific publications in the medical literature. 1 The findings of these studies were discussed at a joint meeting of the Arthritis Advisory Committee and Drug Safety and Risk Management Advisory Committee held on February 10-11, 2014 (for complete safety reviews, background information, and minutes of this meeting, click here ).

Aspirin represents one of humankind’s oldest pharmaceutical agents and continues to be a mainstay therapy for a variety of indications. Like all drugs, aspirin can be toxic at high doses (greater than 150 milligrams per kilogram body weight), but the benefits of aspirin clearly outweigh the risks. We might consider aspirin a true “wonder drug,” as it has been shown to be useful in the treatment of a variety of conditions beyond fever and pain, including prevention of coronary artery disease, heart attack, and stroke. Recent studies suggest that aspirin may also limit the rate of growth and the occurrence of certain types of cancer, including prostate, colon, pancreatic, and lung cancer. While new drugs will continue to treat these and other diseases, aspirin will always hold a significant place in the history of pharmaceutical agents.

Aspirin and nonsteroidal anti-inflammatory drugs inhibit amyloid-beta aggregation

aspirin and nonsteroidal anti-inflammatory drugs inhibit amyloid-beta aggregation

Aspirin represents one of humankind’s oldest pharmaceutical agents and continues to be a mainstay therapy for a variety of indications. Like all drugs, aspirin can be toxic at high doses (greater than 150 milligrams per kilogram body weight), but the benefits of aspirin clearly outweigh the risks. We might consider aspirin a true “wonder drug,” as it has been shown to be useful in the treatment of a variety of conditions beyond fever and pain, including prevention of coronary artery disease, heart attack, and stroke. Recent studies suggest that aspirin may also limit the rate of growth and the occurrence of certain types of cancer, including prostate, colon, pancreatic, and lung cancer. While new drugs will continue to treat these and other diseases, aspirin will always hold a significant place in the history of pharmaceutical agents.

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